2095768-46-8
2095768-46-8
Chemical Structure
PF-CBP2
- CAS No.: 2095768-46-8
- Formula:C27H32N4O3
- Molecular Weight:460.58
IUPAC Name: 4-(2-(5-(3,5-dimethylisoxazol-4-yl)-2-(4-methoxyphenethyl)-1H-pyrrolo[3,2-b]pyridin-1-yl)ethyl)morpholine
InChIKey: HHMYGKFULLRKST-UHFFFAOYSA-N
SMILES: N=1OC(=C(C2=NC=3C=C(N(C3C=C2)CCN4CCOCC4)CCC5=CC=C(OC)C=C5)C1C)C
Biological Activity: PF-CBP2 is a selective CREBBP inhibitor with an IC50 of 170 nM for CREBBP. PF-CBP2 exhibits activity against EP300[1][2].
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PF-CBP2 | PF-CBP2 is a selective CREBBP inhibitor with an IC50 of 170 nM for CREBBP. PF-CBP2 exhibits activity against EP300. | |||||||||||||||||||||
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References
- [1]. Denny RA, et al. Structure-Based Design of Highly Selective Inhibitors of the CREB Binding Protein Bromodomain. Journal of medicinal chemistry. 2017 Jul 13;60(13):5349-5363.
- [2]. Liu M, et al. Recent Advances on Small-Molecule Bromodomain-Containing Histone Acetyltransferase Inhibitors. J Med Chem. 2023 Feb 9;66(3):1678-1699.
