PF-CBP2
PF-CBP2 is a selective CREBBP inhibitor with an IC50 of 170 nM for CREBBP. PF-CBP2 exhibits activity against EP300.
For research use only. We do not sell to patients.
- CAS No.: 2095768-46-8
- Formula: C27H32N4O3
- Molecular Weight:460.58
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
[1]|
CREBBP 170 nM (IC50) |
EP300 |
BRD4 18.4 μM (IC50) |
In Vitro
PF-CBP2 inhibits the CREBBP bromodomain in FRET assays with an IC50 of 0.17 μM[1].
PF-CBP2 binds weakly to BRD4 with an IC50 of 18.4 μM and exhibits more than 100-fold biochemical selectivity for CREBBP[1].
PF-CBP2 (2 μM) exhibits a passive permeability rate of 6.8 μcm/s in cell permeability assays[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2095768-46-8
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Molecular Weight 460.58
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Formula C27H32N4O3
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SMILES
N=1OC(=C(C2=NC=3C=C(N(C3C=C2)CCN4CCOCC4)CCC5=CC=C(OC)C=C5)C1C)C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PF-CBP2 Related Classifications
HY-181417 Related Classifications
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