2108899-91-6
Chemical Structure
CPTH2 hydrochloride
- CAS No.: 2108899-91-6
- Formula:C14H15Cl2N3S
- Molecular Weight:328.26
IUPAC Name: 4-(4-chlorophenyl)-2-(2-cyclopentylidenehydrazinyl)thiazole hydrochloride
InChIKey: ODVWZAKKCNHATB-UHFFFAOYSA-N
SMILES: ClC1=CC=C(C2=CSC(N/N=C3CCCC/3)=N2)C=C1.[H]Cl
Biological Activity: CPTH2 hydrochloride is a potent histone acetyltransferase (HAT) inhibitor. CPTH2 hydrochloride selectively inhibits the acetylation of histone H3 by Gcn5. CPTH2 hydrochloride induces apoptosis and decreases the invasiveness of a clear cell renal carcinoma (ccRCC) cell line through the inhibition of acetyltransferase p300 (KAT3B)[1][2].
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CPTH2 hydrochloride | CPTH2 hydrochloride is a potent histone acetyltransferase (HAT) inhibitor. CPTH2 hydrochloride selectively inhibits the acetylation of histone H3 by Gcn5. CPTH2 hydrochloride induces apoptosis and decreases the invasiveness of a clear cell renal carcinoma (ccRCC) cell line through the inhibition of acetyltransferase p300 (KAT3B). | |||||||||||||||||||||
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- [1]. Cocco E, et al. KAT3B-p300 and H3AcK18/H3AcK14 levels are prognostic markers for kidney ccRCC tumoraggressiveness and target of KAT inhibitor CPTH2. Clin Epigenetics. 2018 Apr 4;10:44. [Content Brief]
- [2]. Chimenti F, et al. A novel histone acetyltransferase inhibitor modulating Gcn5 network: cyclopentylidene-[4-(4'-chlorophenyl)thiazol-2-yl)hydrazone. J Med Chem. 2009 Jan 22;52(2):530-6. [Content Brief]
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