211230-67-0
Chemical Structure
ONO-AE 248
- CAS. Nr.: 211230-67-0
- Formula:C22H36O5
- Molecular Weight:380.52
IUPAC Name: (Z)-7-((1R,2R,3R)-3-methoxy-2-((S,E)-3-methoxyoct-1-en-1-yl)-5-oxocyclopentyl)hept-5-enoic acid
InChIKey: MXDQOCKVVLKVJS-QKIVIXBWSA-N
SMILES: CCCCC[C@H](OC)/C=C/[C@@H]1[C@H](C(C[C@H]1OC)=O)C/C=C\CCCC(O)=O
Biological Activity: ONO-AE 248 is a selective EP3 receptor agonist with cardioprotective activity. ONO-AE 248 reduces myocardial infarction size by selectively binding to the EP3α receptor in mice. The cardioprotective effect of ONO-AE 248 is independent of hemodynamic effects. The mechanism of ONO-AE 248 may involve activation of protein kinase C and opening of K(ATP) channels[1].
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ONO-AE 248 | 98.27% | ONO-AE 248 is a selective EP3 receptor agonist with cardioprotective activity. ONO-AE 248 reduces myocardial infarction size by selectively binding to the EP3α receptor in mice. The cardioprotective effect of ONO-AE 248 is independent of hemodynamic effects. The mechanism of ONO-AE 248 may involve activation of protein kinase C and opening of K(ATP) channels. | ||||||||||||||||||||
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