211513-37-0
211513-37-0
Chemical Structure
Dalcetrapib
Synonym(s): JTT-705; RO4607381
- CAS No.: 211513-37-0
- Formula:C23H35NO2S
- Molecular Weight:389.59
IUPAC Name: S-(2-(1-(2-ethylbutyl)cyclohexane-1-carboxamido)phenyl) 2-methylpropanethioate
InChIKey: YZQLWPMZQVHJED-UHFFFAOYSA-N
SMILES: CC(C)C(SC1=C(NC(C2(CC(CC)CC)CCCCC2)=O)C=CC=C1)=O
Biological Activity: Dalcetrapib (JTT-705) is an orally active cholesteryl ester transfer protein (CETP) inhibitor with IC50s of 204.6 nM and 6 μM against recombinant human (rh) CETP and human plasma CETP, respectively[1][2].
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Dalcetrapib | 99.19% | Dalcetrapib (JTT-705) is an orally active cholesteryl ester transfer protein (CETP) inhibitor with IC50s of 204.6 nM and 6 μM against recombinant human (rh) CETP and human plasma CETP, respectively. | ||||||||||||||||||||
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Dalcetrapib (Standard) | ≥98% | Dalcetrapib (Standard) is the analytical standard of Dalcetrapib. This product is intended for research and analytical applications. Dalcetrapib (JTT-705) is an orally active cholesteryl ester transfer protein (CETP) inhibitor with IC50s of 204.6 nM and 6 μM against recombinant human (rh) CETP and human plasma CETP, respectively. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.52
HY-157187Fenhexamid-1-pentanoic acid -
Similarity Score 0.50
HY-147131CDK9-IN-30 -
Similarity Score 0.49
HY-133828Cinanserin -
Similarity Score 0.48
HY-171478SQ 11,447 -
Similarity Score 0.48
HY-18594NSC-41589 -
Similarity Score 0.48
HY-100943RCinanserin hydrochloride (Standard) -
Similarity Score 0.48
HY-118065RFenhexamid (Standard) -
Similarity Score 0.48
HY-Z2199Cabozantinib impurity 1 -
Similarity Score 0.46
HY-186011CPAG-1 -
Explore the MedChemAI to find more analogs
References
- [1]. Niesor EJ, et al. Modulating cholesteryl ester transfer protein activity maintains efficient pre-β-HDL formation and increases reverse cholesterol transport. J Lipid Res. 2010, 51(12), 3443-3454. [Content Brief]
- [2]. Shinkai H, et al. J Med Chem. bis(2-(Acylamino)phenyl) disulfides, 2-(acylamino)benzenethiols, and S-(2-(acylamino)phenyl) alkanethioates as novel inhibitors of cholesteryl ester transfer protein. 2000, 43(19), 3566-3572. [Content Brief]
