2120398-41-4
2120398-41-4
Chemical Structure
CHK1-IN-4
- CAS No.: 2120398-41-4
- Formula:C18H18BrN7O2
- Molecular Weight:444.29
IUPAC Name: 5-((5-(2-(3-aminopropoxy)-4-bromo-6-methoxyphenyl)-1H-pyrazol-3-yl)amino)pyrazine-2-carbonitrile
InChIKey: LWOYEDQROLTYBT-UHFFFAOYSA-N
SMILES: N#CC1=NC=C(NC2=NNC(C3=C(OC)C=C(Br)C=C3OCCCN)=C2)N=C1
Biological Activity: CHK1-IN-4 is a selective checkpoint kinase 1 (Chk1) inhibitor with an IC50 ≤ 1 nM. The IC50 value of CHK1-IN-4 against Chk2 ranges from 50 to 100 nM. CHK1-IN-4 inhibits cancer cell proliferation and exhibits antitumor activity in colon cancer xenograft models. CHK1-IN-4 can be used for the research of colon cancer and breast cancer[1].
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CHK1-IN-4 | CHK1-IN-4 is a selective checkpoint kinase 1 (Chk1) inhibitor with an IC50 ≤ 1 nM. The IC50 value of CHK1-IN-4 against Chk2 ranges from 50 to 100 nM. CHK1-IN-4 inhibits cancer cell proliferation and exhibits antitumor activity in colon cancer xenograft models. CHK1-IN-4 can be used for the research of colon cancer and breast cancer. | |||||||||||||||||||||
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