2170274-53-8
2170274-53-8
Chemical Structure
SPC-180002
- CAS No.: 2170274-53-8
- Formula:C18H23NO4
- Molecular Weight:317.38
InChIKey: FHLFSJJWOMHMOR-UHFFFAOYSA-N
SMILES: O=C(C(CN(CCC1=CC=CC=C1)CC(C(OC)=O)=C)=C)OC
Biological Activity: SPC-180002 is a SIRT1/3 dual inhibitor, with IC50 values of 1.13 and 5.41 μM, respectively. SPC-180002 disturbs redox homeostasis via ROS generation, which leads to an increase in both p21 protein stability and mitochondrial dysfunction. SPC-180002 strongly inhibits cell cycle progression and cancer cell growth. SPC-180002 activates the Nrf2 signaling pathway[1].
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SPC-180002 | SPC-180002 is a SIRT1/3 dual inhibitor, with IC50 values of 1.13 and 5.41 μM, respectively. SPC-180002 disturbs redox homeostasis via ROS generation, which leads to an increase in both p21 protein stability and mitochondrial dysfunction. SPC-180002 strongly inhibits cell cycle progression and cancer cell growth. SPC-180002 activates the Nrf2 signaling pathway. | |||||||||||||||||||||
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References
Keywords
