SPC-180002
SPC-180002 is a SIRT1/3 dual inhibitor, with IC50 values of 1.13 and 5.41 μM, respectively. SPC-180002 disturbs redox homeostasis via ROS generation, which leads to an increase in both p21 protein stability and mitochondrial dysfunction. SPC-180002 strongly inhibits cell cycle progression and cancer cell growth. SPC-180002 activates the Nrf2 signaling pathway.
For research use only. We do not sell to patients.
- CAS No.: 2170274-53-8
- Formula: C18H23NO4
- Molecular Weight:317.38
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
|
SIRT1 1.13 ± 0.3 μM (IC50) |
SIRT3 5.41 ± 4.8 μM (IC50) |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:Five weeks female athymic nude mice (BALB/c)[1]
-
Dosage:1 mg/kg or 5 mg/kg
-
Administration:i.p., twice a week
-
Result:Significantly impeded tumor progression. The gain of tumor volume in SPC-180002-treated mice was significantly reduced by 48% at the low dose (1 mg/kg) and by 52% at the high dose (5 mg/kg), compared to vehicle-treated mice.
Chemical Information
-
CAS No. 2170274-53-8
-
Molecular Weight 317.38
-
Formula C18H23NO4
-
SMILES
O=C(C(CN(CCC1=CC=CC=C1)CC(C(OC)=O)=C)=C)OC
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Powered by Bioz