2180931-49-9
Chemical Structure
LQFM030
- CAS No.: 2180931-49-9
- Formula:C16H19ClN4O
- Molecular Weight:318.80
IUPAC Name: 1-(4-((1-(4-chlorophenyl)-1H-pyrazol-4-yl)methyl)piperazin-1-yl)ethan-1-one
InChIKey: QHKXDHJQHJXHGV-UHFFFAOYSA-N
SMILES: CC(N1CCN(CC2=CN(C3=CC=C(Cl)C=C3)N=C2)CC1)=O
Biological Activity: LQFM030 is a novel small molecule MDM2 inhibitor. LQFM030 exhibits concentration dependent cytotoxicity in K562 cells (IC50 = 0.28 mM). LQFM030 induces cell apoptosis through G0/G1 phase cell cycle arrest and increased Caspase activity. LQFM030 downregulates the mRNA expression of MDM2, MDMX, p73, MYC, and NF-κB. LQFM030 is commonly used in research on cancers such as leukemia[1].
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LQFM030 | LQFM030 is a novel small molecule MDM2 inhibitor. LQFM030 exhibits concentration dependent cytotoxicity in K562 cells (IC50 = 0.28 mM). LQFM030 induces cell apoptosis through G0/G1 phase cell cycle arrest and increased Caspase activity. LQFM030 downregulates the mRNA expression of MDM2, MDMX, p73, MYC, and NF-κB. LQFM030 is commonly used in research on cancers such as leukemia. | |||||||||||||||||||||
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Keywords
