219843-75-1
219843-75-1
Chemical Structure
5,6-Dihydroabiraterone
- CAS No.: 219843-75-1
- Formula:C24H33NO
- Molecular Weight:351.52
IUPAC Name: (3S,5S,8R,9S,10S,13S,14S)-10,13-dimethyl-17-(pyridin-3-yl)-2,3,4,5,6,7,8,9,10,11,12,13,14,15-tetradecahydro-1H-cyclopenta[a]phenanthren-3-ol
InChIKey: UNJQRCXVHBZVTM-LDBGNEBASA-N
SMILES: C[C@@]12C(C3=CC=CN=C3)=CC[C@@]1([H])[C@]4([H])CC[C@@]5([H])C[C@@H](O)CC[C@]5(C)[C@@]4([H])CC2
Biological Activity: 5,6-Dihydroabiraterone is the metabolism of Abiraterone (HY-70013). Abiraterone is a potent and irreversible CYP17A1 inhibitor with antiandrogen activity, and shows antitumor activity in CRPC (castration-resistant prostate cancer)[1][2].
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5,6-Dihydroabiraterone | 96.51% | 5,6-Dihydroabiraterone is the metabolism of Abiraterone (HY-70013). Abiraterone is a potent and irreversible CYP17A1 inhibitor with antiandrogen activity, and shows antitumor activity in CRPC (castration-resistant prostate cancer). | ||||||||||||||||||||
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References
- [1]. Alyamani M, et al. Development and validation of a novel LC-MS/MS method for simultaneous determination of abiraterone and its seven steroidal metabolites in human serum: Innovation in separation of diastereoisomers without use of a chiral column. J Steroid Biochem Mol Biol. 2017 Sep;172:231-239. [Content Brief]
- [2]. Attard G, et al. Phase I clinical trial of a selective inhibitor of CYP17, abiraterone acetate, confirms that castration-resistant prostate cancer commonly remains hormone driven. J Clin Oncol. 2008 Oct 1;26(28):4563-71. [Content Brief]
