22044-58-2
22044-58-2
Chemical Structure
Derrubone
- CAS No.: 22044-58-2
- Formula:C21H18O6
- Molecular Weight:366.36
InChIKey: FTBGFGQPUMCUSC-UHFFFAOYSA-N
SMILES: O=C1C(C2=CC3=C(OCO3)C=C2)=COC4=CC(O)=C(C/C=C(C)\C)C(O)=C14
Biological Activity: Derrubone is a prenylated isoflavone Hsp90 inhibitor that binds to the C-terminal ATP site of Hsp90α, stabilizes the Hsp90-client protein co-chaperone complex, and induces client protein degradation, thereby inhibiting cancer cell proliferation. Derrubone can be used for research on breast cancer, colon cancer, Alzheimer's disease, and type 2 diabetes[1][2].
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Derrubone | Derrubone is a prenylated isoflavone Hsp90 inhibitor that binds to the C-terminal ATP site of Hsp90α, stabilizes the Hsp90-client protein co-chaperone complex, and induces client protein degradation, thereby inhibiting cancer cell proliferation. Derrubone can be used for research on breast cancer, colon cancer, Alzheimer's disease, and type 2 diabetes. | |||||||||||||||||||||
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