221148-46-5
221148-46-5
Chemical Structure
GW-406381
- CAS No.: 221148-46-5
- Formula:C21H19N3O3S
- Molecular Weight:393.46
IUPAC Name: 2-(4-ethoxyphenyl)-3-(4-(methylsulfonyl)phenyl)pyrazolo[1,5-b]pyridazine
InChIKey: NXMZBNYLCVTRGB-UHFFFAOYSA-N
SMILES: O=S(C1=CC=C(C=C1)C2=C3C=CC=NN3N=C2C4=CC=C(C=C4)OCC)(C)=O
Biological Activity: GW406381, a highly selective cyclooxygenase-2 (COX-2) inhibitor, attenuates spontaneous ectopic discharge in sural nerves of rats following chronic constriction injury[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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GW-406381 | 99.0% | GW406381, a highly selective cyclooxygenase-2 (COX-2) inhibitor, attenuates spontaneous ectopic discharge in sural nerves of rats following chronic constriction injury. | ||||||||||||||||||||
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References
- [1]. Zhao FY, et al. GW406381, a novel COX-2 inhibitor, attenuates spontaneous ectopic discharge in sural nerves of rats following chronic constriction injury. Pain. 2007 Mar;128(1-2):78-87. [Content Brief]
- [2]. Boswell DJ, et al. Evaluation of GW406381 for treatment of osteoarthritis of the knee: two randomized, controlled studies. Medscape J Med. 2008;10(11):259. [Content Brief]
