22191-97-5
Chemical Structure
BF-170
- CAS No.: 22191-97-5
- Formula:C15H12N2
- Molecular Weight:220.27
IUPAC Name: 4-(quinolin-2-yl)aniline
InChIKey: PWLMSCCFNGGPGM-UHFFFAOYSA-N
SMILES: C1=CC=C2C(=C1)C=CC(=N2)C3=CC=C(C=C3)N
Biological Activity: BF-170 is a selective tau fibril binding agent with an EC50 of 221 nM. It exhibits good blood-brain barrier permeability, and after intravenous injection in mice, the concentration in brain tissue reaches 9.1% ID/g within 2 minutes (with a brain clearance rate of 0.25% ID/g after 30 minutes). BF-170 can be used as a probe for tau protein pathology imaging in Alzheimer's disease (AD). It plays an important role in early-stage AD research and holds potential for imaging studies of tau-related neurodegenerative diseases[1].
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BF-170 | 99.74% | BF-170 is a selective tau fibril binding agent with an EC50 of 221 nM. It exhibits good blood-brain barrier permeability, and after intravenous injection in mice, the concentration in brain tissue reaches 9.1% ID/g within 2 minutes (with a brain clearance rate of 0.25% ID/g after 30 minutes). BF-170 can be used as a probe for tau protein pathology imaging in Alzheimer's disease (AD). It plays an important role in early-stage AD research and holds potential for imaging studies of tau-related neurodegenerative diseases. | ||||||||||||||||||||
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Keywords
