2. Neuronal Signaling
  3. Tau Protein
  4. BF-170

BF-170 is a selective tau fibril binding agent with an EC50 of 221 nM. It exhibits good blood-brain barrier permeability, and after intravenous injection in mice, the concentration in brain tissue reaches 9.1% ID/g within 2 minutes (with a brain clearance rate of 0.25% ID/g after 30 minutes). BF-170 can be used as a probe for tau protein pathology imaging in Alzheimer's disease (AD). It plays an important role in early-stage AD research and holds potential for imaging studies of tau-related neurodegenerative diseases.

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BF-170

BF-170 Chemical Structure

CAS No. : 22191-97-5

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BF-170 Related Antibodies

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Description

BF-170 is a selective tau fibril binding agent with an EC50 of 221 nM. It exhibits good blood-brain barrier permeability, and after intravenous injection in mice, the concentration in brain tissue reaches 9.1% ID/g within 2 minutes (with a brain clearance rate of 0.25% ID/g after 30 minutes). BF-170 can be used as a probe for tau protein pathology imaging in Alzheimer's disease (AD). It plays an important role in early-stage AD research and holds potential for imaging studies of tau-related neurodegenerative diseases[1].

Molecular Weight

220.27

Formula

C15H12N2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

C1=CC=C2C(=C1)C=CC(=N2)C3=CC=C(C=C3)N
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

1 M HCl : ≥ 100 mg/mL (453.99 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.5399 mL 22.6994 mL 45.3988 mL
5 mM 0.9080 mL 4.5399 mL 9.0798 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
1 M HCl 1 mM 4.5399 mL 22.6994 mL 45.3988 mL 113.4971 mL
5 mM 0.9080 mL 4.5399 mL 9.0798 mL 22.6994 mL
10 mM 0.4540 mL 2.2699 mL 4.5399 mL 11.3497 mL
15 mM 0.3027 mL 1.5133 mL 3.0266 mL 7.5665 mL
20 mM 0.2270 mL 1.1350 mL 2.2699 mL 5.6749 mL
25 mM 0.1816 mL 0.9080 mL 1.8160 mL 4.5399 mL
30 mM 0.1513 mL 0.7566 mL 1.5133 mL 3.7832 mL
40 mM 0.1135 mL 0.5675 mL 1.1350 mL 2.8374 mL
50 mM 0.0908 mL 0.4540 mL 0.9080 mL 2.2699 mL
60 mM 0.0757 mL 0.3783 mL 0.7566 mL 1.8916 mL
80 mM 0.0567 mL 0.2837 mL 0.5675 mL 1.4187 mL
100 mM 0.0454 mL 0.2270 mL 0.4540 mL 1.1350 mL
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BF-170 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BF-17022191-97-5BF170BF 170Tau ProteinInhibitorinhibitorinhibit

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