2228052-37-5
2228052-37-5
Chemical Structure
A-1155905
- CAS No.: 2228052-37-5
- Formula:C46H51FN6O6
- Molecular Weight:802.93
InChIKey: MBGDINGAPVYVHY-UHFFFAOYSA-N
SMILES: O=C(C)N(CC1)CCN1C2=CC=C(OCC3=C(C4=C(N(CCN5CCOCC5)C(C(O)=O)=C6CCCOC7=C(C=CC=C8F)C8=CC=C7)C6=CC=C4)C(C)=NN3C)C=C2
Biological Activity: A-1155905 is a MCL-1 inhibitor (IC50=33.5 nM; Ki=0.58 nM) with anticancer activity. A-1155905 selectively binds to MCL-1 with sufficient affinity to disrupt the MCL-1-bim complex in living cells. A-1155905-induced death of MCL-1-dependent cell lines is caspase-dependent and occurs via apoptosis[1].
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A-1155905 | A-1155905 is a MCL-1 inhibitor (IC50=33.5 nM; Ki=0.58 nM) with anticancer activity. A-1155905 selectively binds to MCL-1 with sufficient affinity to disrupt the MCL-1-bim complex in living cells. A-1155905-induced death of MCL-1-dependent cell lines is caspase-dependent and occurs via apoptosis. | |||||||||||||||||||||
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References
Keywords
