2230715-40-7
2230715-40-7
Chemical Structure
AM-8722
- CAS No.: 2230715-40-7
- Formula:C27H30ClN5O5
- Molecular Weight:540.01
InChIKey: CUPUIWBDRFRTJJ-UHFFFAOYSA-N
SMILES: O=C1C=CC2=C(N1CCO)C(CCC34OCC(CC3)(CC4)NCC5=NC(N6)=C(C=C5)OCC6=O)=C(Cl)C=N2
Biological Activity: AM-8722 is an orally active inhibitor of bacterial DNA gyrase and topoisomerase IV. AM-8722 inhibits bacterial DNA synthesis and exhibits broad-spectrum antibacterial activity against Gram-positive and Gram-negative pathogens. AM-8722 can be used for research on bacterial septicemia and bacterial infections[1][2].
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AM-8722 | AM-8722 is an orally active inhibitor of bacterial DNA gyrase and topoisomerase IV. AM-8722 inhibits bacterial DNA synthesis and exhibits broad-spectrum antibacterial activity against Gram-positive and Gram-negative pathogens. AM-8722 can be used for research on bacterial septicemia and bacterial infections. | |||||||||||||||||||||
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References
- [1]. Tan CM, et al. In Vitro and In Vivo Characterization of the Novel Oxabicyclooctane-Linked Bacterial Topoisomerase Inhibitor AM-8722, a Selective, Potent Inhibitor of Bacterial DNA Gyrase. Antimicrobial agents and chemotherapy. 2016 Aug;60(8):4830-9.
- [2]. Singh SB, et al. Structure activity relationship of N-1 substituted 1,5-naphthyrid-2-one analogs of oxabicyclooctane-linked novel bacterial topoisomerase inhibitors as broad-spectrum antibacterial agents (Part-9). Bioorganic & medicinal chemistry letters. 2022 Nov 01;75:128808.
