2238822-07-4
Chemical Structure
GDC-2394
- CAS No.: 2238822-07-4
- Formula:C20H25N5O4S
- Molecular Weight:431.51
IUPAC Name: (S)-3-(3-(((allyloxy)carbonyl)amino)phenyl)-2-((tert-butoxycarbonyl)(methyl)amino)-3-methylbutanoic acid
InChIKey: NDRARVKETDZHBS-AWEZNQCLSA-N
SMILES: O=S(C1=C2OC[C@@H](NC)CN2N=C1)(NC(NC3=C4CCCC4=CC5=C3CCC5)=O)=O
Biological Activity: GDC-2394 is an orally active and selective NLRP3 inhibitor, and also inhibits IL-1β with IC50s of 0.4 μM (human IL-1β) and 0.1 μM (mouse IL-1β). GDC-2394 inhibits NLRP3-induced caspase-1 activity without inhibiting NLRC4-dependent inflammasome activation. GDC-2394 could be used to study gouty arthritis.
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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GDC-2394 | 99.87% | GDC-2394 is an orally active and selective NLRP3 inhibitor, and also inhibits IL-1β with IC50s of 0.4 μM (human IL-1β) and 0.1 μM (mouse IL-1β). GDC-2394 inhibits NLRP3-induced caspase-1 activity without inhibiting NLRC4-dependent inflammasome activation. GDC-2394 could be used to study gouty arthritis. | ||||||||||||||||||||
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Keywords
