2260669-09-6
Chemical Structure
4A-MPLA ammonium
- CAS No.: 2260669-09-6
- Formula:C68H132N3O19P
- Molecular Weight:1326.76
IUPAC Name: (2S,3R,4R,5S,6R)-2,5-dihydroxy-6-((((2R,3R,4R,5S,6R)-4-hydroxy-6-(hydroxymethyl)-5-(phosphonooxy)-3-((R)-3-(tetradecanoyloxy)tetradecanamido)tetrahydro-2H-pyran-2-yl)oxy)methyl)-3-((R)-3-hydroxytetradecanamido)tetrahydro-2H-pyran-4-yl (R)-3-hydroxytetradecanoate, ammonia salt
InChIKey: KREAPURBNFKEHO-BNSRHSNQSA-N
SMILES: O[C@@H]([C@@H]([C@H]([C@H](O1)O)NC(C[C@@H](CCCCCCCCCCC)O)=O)OC(C[C@H](O)CCCCCCCCCCC)=O)[C@H]1CO[C@H]2[C@@H]([C@H]([C@@H]([C@H](O2)CO)OP(O)(O)=O)O)NC(C[C@@H](CCCCCCCCCCC)OC(CCCCCCCCCCCCC)=O)=O.N
Biological Activity: 4A-MPLA ammonium is an orally active TLR4 agonist. 4A-MPLA ammonium induces TLR4 endocytosis dependent on Cdc42 and galectin-3, triggering TRIF-mediated signaling and sustained IFN-β production. 4A-MPLA ammonium promotes lipid droplet formation, upregulates interferon-stimulated genes and type I IFN signaling genes, downregulates lysosome/phagosome function genes, and modulates tolerogenic dendritic cell function. 4A-MPLA ammonium can be used for the research of colitis[1][2][3].
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4A-MPLA ammonium | 4A-MPLA ammonium is an orally active TLR4 agonist. 4A-MPLA ammonium induces TLR4 endocytosis dependent on Cdc42 and galectin-3, triggering TRIF-mediated signaling and sustained IFN-β production. 4A-MPLA ammonium promotes lipid droplet formation, upregulates interferon-stimulated genes and type I IFN signaling genes, downregulates lysosome/phagosome function genes, and modulates tolerogenic dendritic cell function. 4A-MPLA ammonium can be used for the research of colitis. | |||||||||||||||||||||
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References
- [1]. Cho HS, et al. Structure of gut microbial glycolipid modulates host inflammatory response. Cell. 2025;188(19):5295-5312.e18. [Content Brief]
- [2]. Starling S. Commensal glycolipid structure shapes gut immunity. Nat Rev Microbiol. 2025 Oct;23(10):617. [Content Brief]
- [3]. Zhang Y, et al. Diversity of oligosaccharides in lipooligosaccharides of Akkermansia muciniphila and its anti-atherosclerotic activity. Nat Prod Bioprospect. 2026;16(1):58. Published 2026 May 2. [Content Brief]
