2281803-33-4
Chemical Structure
MEK/PI3K-IN-2
- CAS No.: 2281803-33-4
- Formula:C38H41F5IN9O7
- Molecular Weight:957.68
IUPAC Name: N-((3-(4-(2-(difluoromethyl)-1H-benzo[d]imidazol-1-yl)-6-morpholino-1,3,5-triazin-2-yl)-1-hydroxy-6,9,12-trioxa-3-azatetradecan-14-yl)oxy)-3,4-difluoro-2-((2-fluoro-4-iodophenyl)amino)benzamide
InChIKey: VAPPIXLSHDYSCY-UHFFFAOYSA-N
SMILES: O=C(C1=C(C(F)=C(C=C1)F)NC2=CC=C(C=C2F)I)NOCCOCCOCCOCCN(C3=NC(N4CCOCC4)=NC(N5C(C(F)F)=NC6=C5C=CC=C6)=N3)CCO
Biological Activity: MEK/PI3K-IN-2 (compound 6s) is a potent MEK/PI3K inhibitor, with IC50 values of 352 nM (MEK1), 107 nM (PI3Kα), and 137 nM (PI3Kδ), respectively. MEK/PI3K-IN-2 suppresses pAKT and pERK1/2 levels. MEK/PI3K-IN-2 shows anti-proliferative activity against tumor cell lines[1].
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MEK/PI3K-IN-2 | MEK/PI3K-IN-2 (compound 6s) is a potent MEK/PI3K inhibitor, with IC50 values of 352 nM (MEK1), 107 nM (PI3Kα), and 137 nM (PI3Kδ), respectively. MEK/PI3K-IN-2 suppresses pAKT and pERK1/2 levels. MEK/PI3K-IN-2 shows anti-proliferative activity against tumor cell lines. | |||||||||||||||||||||
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Keywords
