2291360-73-9
Chemical Structure
NVP-DKY709
- CAS No.: 2291360-73-9
- Formula:C25H27N3O3
- Molecular Weight:417.50
IUPAC Name: 3-(5-(1-benzylpiperidin-4-yl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione
InChIKey: OMISHRJQMYQPMG-UHFFFAOYSA-N
SMILES: O=C1CCC(C(N1)=O)N2CC3=CC(C4CCN(CC4)CC5=CC=CC=C5)=CC=C3C2=O
Biological Activity: NVP-DKY709 is an orally active and selective IKZF2 molecular glue degrader with the Dmax and DC50 of 53% and 4 nM, respectively. In addition, NVP-DKY709 can degrade IKZF4 (DC50: 13 nM) and SALL4 (DC50: 2 nM). NVP-DKY709 exerts anti-tumor activity by binding with CRBN to change conformation and recruit and degrade IKZF2[1][2].
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NVP-DKY709 | 99.66% | NVP-DKY709 is an orally active and selective IKZF2 molecular glue degrader with the Dmax and DC50 of 53% and 4 nM, respectively. In addition, NVP-DKY709 can degrade IKZF4 (DC50: 13 nM) and SALL4 (DC50: 2 nM). NVP-DKY709 exerts anti-tumor activity by binding with CRBN to change conformation and recruit and degrade IKZF2. | ||||||||||||||||||||
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- [1]. Bonazzi S, et al. Discovery and characterization of a selective IKZF2 glue degrader for cancer immunotherapy. Cell Chem Biol. 2023 Mar 16;30(3):235-247.e12. [Content Brief]
- [2]. Simone BONAZZI, et al. Dosing regimen and pharmaceutical combination comprising 3-(1-oxoisoindolin-2-yl)piperidine-2,6-dione derivatives. WO2020128972 A1.
Keywords
