234085-20-2
Chemical Structure
MGS0008
- CAS No.: 234085-20-2
- Formula:C8H10FNO4
- Molecular Weight:203.17
IUPAC Name: (1S,2S,3S,5R,6S)-2-amino-3-fluorobicyclo[3.1.0]hexane-2,6-dicarboxylic acid
InChIKey: DIWVNJFXRKZAGI-FJNNMDBYSA-N
SMILES: O=C([C@@]1(N)[C@]2([H])[C@@H](C(O)=O)[C@]2([H])C[C@@H]1F)O
Biological Activity: MGS0008 is an orally active and brain-penetrant metabotropic glutamate receptor 2/3 (mGlu2/3) agonist with EC50 values of 29.4 nM and 45.4 nM for mGluR2 and mGluR3, respectively. MGS0008 is promising for research of central nervous system disorders, including schizophrenia, anxiety, and neurodegenerative diseases[1][2].
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MGS0008 | MGS0008 is an orally active and brain-penetrant metabotropic glutamate receptor 2/3 (mGlu2/3) agonist with EC50 values of 29.4 nM and 45.4 nM for mGluR2 and mGluR3, respectively. MGS0008 is promising for research of central nervous system disorders, including schizophrenia, anxiety, and neurodegenerative diseases. | |||||||||||||||||||||
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- [1]. Ochi M, et al. Bottom-up physiologically based pharmacokinetic modelling for predicting the human pharmacokinetic profiles of the ester prodrug MGS0274 and its active metabolite MGS0008, a metabotropic glutamate 2/3 receptor agonist. Xenobiotica. 2022 Feb;52(2):119-128. [Content Brief]
- [2]. Nakazato A, et al. Synthesis, SARs, and pharmacological characterization of 2-amino-3 or 6-fluorobicyclo[3.1.0]hexane-2,6-dicarboxylic acid derivatives as potent, selective, and orally active group II metabotropic glutamate receptor agonists. J Med Chem. 2000 Dec 14;43(25):4893-909. [Content Brief]
Keywords
