2359618-49-6
Chemical Structure
(S)-GSK1379725A
- CAS No.: 2359618-49-6
- Formula:C23H23FN6O3
- Molecular Weight:450.47
IUPAC Name: (2R,4S)-4-(3-chlorophenyl)-2-((((R)-1-(4-hydroxy-3-isopropylphenyl)-7-methyl-2,3-dihydro-1H-inden-5-yl)oxy)methyl)-1,3,2-dioxaphosphinane 2-oxide
InChIKey: LLVPDBRSUHNJQQ-IBGZPJMESA-N
SMILES: COC(C1=CC=CC(NC(N[C@@H](CC2)CN2C3=NC(NC4=CC=C(C=C4)F)=NC=C3)=O)=C1)=O
Biological Activity: (S)-GSK1379725A (compound AU1) is a selective bromodomain and PHD finger containing transcription factor (BPTF) bromodomain inhibitor with a Kd of 2.8 μM. (S)-GSK1379725A shows to be selective for BPTF over BRD4 bromodomain. (S)-GSK1379725A shows antimalarial activity[1].
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(S)-GSK1379725A | (S)-GSK1379725A (compound AU1) is a selective bromodomain and PHD finger containing transcription factor (BPTF) bromodomain inhibitor with a Kd of 2.8 μM. (S)-GSK1379725A shows to be selective for BPTF over BRD4 bromodomain. (S)-GSK1379725A shows antimalarial activity. | |||||||||||||||||||||
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Keywords
