23674-86-4
Chemical Structure
Difluprednate
- CAS No.: 23674-86-4
- Formula:C27H34F2O7
- Molecular Weight:508.55
IUPAC Name: (6S,8S,9R,10S,11S,13S,14S,17R)-17-(2-acetoxyacetyl)-6,9-difluoro-11-hydroxy-10,13-dimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl butyrate
InChIKey: WYQPLTPSGFELIB-JTQPXKBDSA-N
SMILES: O=C([C@]([C@]12C)(CC[C@@]1([H])[C@@](C[C@H](F)C3=CC4=O)([H])[C@@](F)([C@]3(C=C4)C)[C@@H](O)C2)OC(CCC)=O)COC(C)=O
Biological Activity: Difluprednate is a glucocorticoid receptor (GC receptor) agonist with a Ki of 0.78 nM. Difluprednate's active metabolite 21-deacetylated difluprednate (DFB) is a competitive agonist of GC receptors with a Ki of 0.061 nM. Difluprednate binds to GC receptors through metabolism to DFB, regulating the transcription of inflammatory mediator genes, thereby exerting anti-inflammatory activity. Difluprednate can be used for research related to ocular inflammation, such as postoperative inflammation, anterior uveitis, etc[1][2].
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Difluprednate | 99.63% | Difluprednate is a glucocorticoid receptor (GC receptor) agonist with a Ki of 0.78 nM. Difluprednate's active metabolite 21-deacetylated difluprednate (DFB) is a competitive agonist of GC receptors with a Ki of 0.061 nM. Difluprednate binds to GC receptors through metabolism to DFB, regulating the transcription of inflammatory mediator genes, thereby exerting anti-inflammatory activity. Difluprednate can be used for research related to ocular inflammation, such as postoperative inflammation, anterior uveitis, etc. | ||||||||||||||||||||
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Difluprednate (Standard) | ≥98% | Difluprednate (Standard) is the analytical standard of Difluprednate. This product is intended for research and analytical applications. Difluprednate is a topical corticosteroid, which is thought to act by the induction of phospholipase A2 inhibitory proteins (lipocortins). Difluprednate is used for the symptomatic treatment of inflammation and pain associated with ocular surgery. | ||||||||||||||||||||
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Difluprednate-d3-1 | Difluprednate-d3-1 is the deuterium labeled Difluprednate (HY-17569). Difluprednate is a glucocorticoid receptor (GC receptor) agonist with a Ki of 0.78 nM. Difluprednate's active metabolite 21-deacetylated difluprednate (DFB) is a competitive agonist of GC receptors with a Ki of 0.061 nM. Difluprednate binds to GC receptors through metabolism to DFB, regulating the transcription of inflammatory mediator genes, thereby exerting anti-inflammatory activity. Difluprednate can be used for research related to ocular inflammation, such as postoperative inflammation, anterior uveitis, etc. | |||||||||||||||||||||
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-
Similarity Score 0.91
HY-Z19661Fluocinolone impurity 1 -
Similarity Score 0.81
HY-107961Diflorasone diacetate -
Similarity Score 0.76
HY-134115Flumethasone 21-acetate -
Similarity Score 0.74
HY-148661Betamethasone acetate impurity 3 -
Similarity Score 0.74
HY-B0775Betamethasone-17-butyrate-21-propionate -
Similarity Score 0.73
HY-B0878RHalobetasol propionate (Standard) -
Similarity Score 0.73
HY-107949Flumethasone pivalate -
Similarity Score 0.72
HY-B1471Fluorometholone acetate -
Similarity Score 0.72
HY-121062Betamethasone acibutate -
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References
- [1]. Tajika T, et al. Metabolic profiles of difluprednate in rabbit ocular tissues after instillation of difluprednate ophthalmic emulsion. Xenobiotica. 2010 Aug;40(8):569-77. [Content Brief]
- [2]. Tajika T, et al. Pharmacokinetic features of difluprednate ophthalmic emulsion in rabbits as determined by glucocorticoid receptor-binding bioassay. J Ocul Pharmacol Ther. 2011 Feb;27(1):29-34. [Content Brief]
