2375554-02-0
2375554-02-0
Chemical Structure
Senexin C
- CAS No.: 2375554-02-0
- Formula:C28H27N5O
- Molecular Weight:449.55
IUPAC Name: 4-((2-(6-(4-methylpiperazine-1-carbonyl)naphthalen-2-yl)ethyl)amino)quinoline-6-carbonitrile
InChIKey: AFUHWZUYZJGVKM-UHFFFAOYSA-N
SMILES: N#CC1=CC=C2N=CC=C(NCCC3=CC=C4C=C(C(N5CCN(C)CC5)=O)C=CC4=C3)C2=C1
Biological Activity: Senexin C is a selective and orally active CDK8/19 inhibitor. Senexin C shows a strong tumor-enrichment pharmacokinetic (PK) profile and tumor-pharmacodynamic (PD) marker responses. Senexin C inhibits the growth of MV4-11 leukemia cells with good tolerability[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Senexin C | 99.19% | Senexin C is a selective and orally active CDK8/19 inhibitor. Senexin C shows a strong tumor-enrichment pharmacokinetic (PK) profile and tumor-pharmacodynamic (PD) marker responses. Senexin C inhibits the growth of MV4-11 leukemia cells with good tolerability. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.81
HY-101800RSenexin B (Standard) -
Similarity Score 0.58
HY-117988SNX2-1-108 -
Similarity Score 0.56
HY-127179ML189 -
Similarity Score 0.53
HY-147371Quinoprazine -
Similarity Score 0.52
HY-149452SJ1008066 -
Similarity Score 0.52
HY-161643S21-1011 -
Similarity Score 0.51
HY-183150HDAC1-IN-13 -
Similarity Score 0.51
HY-107660SIRT2-IN-8 -
Similarity Score 0.50
HY-160799HA-9104 -
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