2375554-02-0
2375554-02-0
Chemical Structure
Senexin C
- CAS 番号: 2375554-02-0
- Formula:C28H27N5O
- Molecular Weight:449.55
IUPAC Name: 4-((2-(6-(4-methylpiperazine-1-carbonyl)naphthalen-2-yl)ethyl)amino)quinoline-6-carbonitrile
InChIKey: AFUHWZUYZJGVKM-UHFFFAOYSA-N
SMILES: N#CC1=CC=C2N=CC=C(NCCC3=CC=C4C=C(C(N5CCN(C)CC5)=O)C=CC4=C3)C2=C1
Biological Activity: Senexin C is a selective and orally active CDK8/19 inhibitor. Senexin C shows a strong tumor-enrichment pharmacokinetic (PK) profile and tumor-pharmacodynamic (PD) marker responses. Senexin C inhibits the growth of MV4-11 leukemia cells with good tolerability[1].
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Senexin C | 99.19% | Senexin C is a selective and orally active CDK8/19 inhibitor. Senexin C shows a strong tumor-enrichment pharmacokinetic (PK) profile and tumor-pharmacodynamic (PD) marker responses. Senexin C inhibits the growth of MV4-11 leukemia cells with good tolerability. | ||||||||||||||||||||
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