2379556-22-4
2379556-22-4
Chemical Structure
TH9619
- CAS No.: 2379556-22-4
- Formula:C17H18FN7O7
- Molecular Weight:451.37
InChIKey: ALGPVOJFIGPPPX-VIFPVBQESA-N
SMILES: NC(NC(N)=NC1=O)=C1CC(NC2=CN=C(C(N[C@H](C(O)=O)CCC(O)=O)=O)C(F)=C2)=O
Biological Activity: TH9619 is a potent inhibitor of dehydrogenase and cyclohydrolase activities in both MTHFD1 and MTHFD2 with a IC50 value of 47 nM, and selectively kills cancer cells. TH9619 induces apoptosis by blocking the S phase. TH9619 has antitumor activity[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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TH9619 | 99.37% | TH9619 is a potent inhibitor of dehydrogenase and cyclohydrolase activities in both MTHFD1 and MTHFD2 with a IC50 value of 47 nM, and selectively kills cancer cells. TH9619 induces apoptosis by blocking the S phase. TH9619 has antitumor activity. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.61
HY-145265-DACTHF -
Similarity Score 0.59
HY-170361MTHFD2-IN-5 -
Similarity Score 0.59
HY-148014TH7299 -
Similarity Score 0.55
HY-1254205-Deazaisofolic acid -
Similarity Score 0.54
HY-125691LY-338979 -
Similarity Score 0.53
HY-155219TH9028 -
Similarity Score 0.53
HY-122250LY 288601 -
Similarity Score 0.53
HY-1223322'-Fluoroaminopterin -
Similarity Score 0.53
HY-1225188-Deazafolic acid -
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References
- [1]. Bonagas N, et al. Pharmacological targeting of MTHFD2 suppresses acute myeloid leukemia by inducing thymidine depletion and replication stress. Nat Cancer. 2022 Feb;3(2):156-172. [Content Brief]
- [2]. Green AC, et al. Formate overflow drives toxic folate trapping in MTHFD1 inhibited cancer cells. Nat Metab. 2023 Apr;5(4):642-659. [Content Brief]
