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Cat. No.: HY-122518

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8-Deazafolic acid

8-Deazafolic acid is an antimicrobial drug for the folate-dependent bacteria, Streptococcus faecium (ATCC 8043) and Lactobacillus casei (ATCC 74691). 8-Deazafolic acid has activity against lymphoid leukemia L1210 in mice.

For research use only. We do not sell to patients.

CAS No.: 51989-25-4
Formula: C₂₀H₂₀N₆O₆
Molecular Weight:440.41

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (264 KB)

8-Deazafolic acid Chemical Structure

CAS No.: 51989-25-4

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

Cellular Effect

Cell Line	Type	Value	Description	References
K562	IC₅₀	55 μM Compound: 8-deazafolate	Ability to inhibit thymidylate synthase derived from human leukemia K562 cells Ability to inhibit thymidylate synthase derived from human leukemia K562 cells	[PMID: 3470522]

Chemical Information

CAS No. 51989-25-4
Molecular Weight 440.41
Formula C₂₀H₂₀N₆O₆
SMILES

O=C(CC[C@H](NC(C1=CC=C(C=C1)NCC2=CC=C(NC(N)=NC3=O)C3=N2)=O)C(O)=O)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (264 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Carroll Temple Jr, et al. New synthesis of N-[4-[[(2-amino-4(3H)-oxopyrido[3,2-d]pyrimidin-6-yl)methyl]amino]benzoyl]-L-glutamic acid (8-deazafolic acid) and the preparation of some 5,6,7,8-tetrahydro derivatives. J. Med. Chem. 1981, 24, 10, 1254–1258.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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