2380166-33-4
Chemical Structure
Zilebesiran
Synonym(s): AD-85481; ALN-AGT
- CAS No.: 2380166-33-4
- Molecular Weight:16389.00
SMILES: [Zilebesiran]
Biological Activity: Zilebesiran (AD-85481; ALN-AGT) is a long-acting liver-targeted small interfering RNA (siRNA) antihypertensive agent. Zilebesiran binds to the hepatic asialoglycoprotein receptor (ASGPR), activates the RNA-induced silencing complex to degrade hepatic angiotensinogen mRNA, thereby inhibiting the gene expression and synthesis of angiotensinogen. Zilebesiran dose-dependently reduces serum angiotensinogen levels and 24-hour ambulatory blood pressure, with its effect persisting throughout the circadian cycle. Zilebesiran is applicable to research related to hypertension[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Zilebesiran | 95.59% | Zilebesiran (AD-85481; ALN-AGT) is a long-acting liver-targeted small interfering RNA (siRNA) antihypertensive agent. Zilebesiran binds to the hepatic asialoglycoprotein receptor (ASGPR), activates the RNA-induced silencing complex to degrade hepatic angiotensinogen mRNA, thereby inhibiting the gene expression and synthesis of angiotensinogen. Zilebesiran dose-dependently reduces serum angiotensinogen levels and 24-hour ambulatory blood pressure, with its effect persisting throughout the circadian cycle. Zilebesiran is applicable to research related to hypertension. | ||||||||||||||||||||
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References
- [1]. Desai AS, et al. Zilebesiran, an RNA Interference Therapeutic Agent for Hypertension. N Engl J Med. 2023;389(3):228-238. [Content Brief]
- [2]. Dudzicz-Gojowy S, et al. Zilebesiran-Small Interfering RNAs as Prospective New Drug in the Treatment of Hypertension. J Clin Med. 2025;14(20):7365. Published 2025 Oct 17. [Content Brief]
