2380300-99-0
2380300-99-0
Chemical Structure
HPK1-IN-34
- CAS No.: 2380300-99-0
- Formula:C25H28N4O2S
- Molecular Weight:448.58
IUPAC Name: 4-(3-(((2-amino-5-(2-(piperidin-4-yl)thiazol-5-yl)pyridin-3-yl)oxy)methyl)phenyl)-2-methylbut-3-yn-2-ol
InChIKey: MKDLEIMJLNBFJO-UHFFFAOYSA-N
SMILES: OC(C)(C)C#CC1=CC=CC(COC2=C(N)N=CC(C3=CN=C(C4CCNCC4)S3)=C2)=C1
Biological Activity: HPK1-IN-34 (Compound 143) is a Hematopoietic progenitor kinase 1 (HPK1) inhibitor with an IC50 of <100 nM[1]. HPK1-IN-34 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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HPK1-IN-34 | 97.49% | HPK1-IN-34 (Compound 143) is a Hematopoietic progenitor kinase 1 (HPK1) inhibitor with an IC50 of <100 nM. HPK1-IN-34 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.89
HY-144088ZYF0033 -
Similarity Score 0.76
HY-144093HPK1/GLK-IN-1 -
Similarity Score 0.48
HY-146231SS47 -
Similarity Score 0.46
HY-153516NIK-IN-2 -
Similarity Score 0.45
HY-110343DBM 1285 dihydrochloride -
Similarity Score 0.45
HY-182238HPK1-IN-69 -
Similarity Score 0.44
HY-167828ARN25062 -
Similarity Score 0.44
HY-172545AMG28 -
Similarity Score 0.43
HY-112809GSK2646264 -
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