2389235-01-0
2389235-01-0
Chemical Structure
Amelenodor
Synonym(s): NX-13
- CAS No.: 2389235-01-0
- Formula:C24H21N3O3
- Molecular Weight:399.44
IUPAC Name: 1,3,5-tris((6-methylpyridin-2-yl)oxy)benzene
InChIKey: OPUQKVNCXCWRLR-UHFFFAOYSA-N
SMILES: CC1=NC(OC2=CC(OC3=CC=CC(C)=N3)=CC(OC4=CC=CC(C)=N4)=C2)=CC=C1
Biological Activity: NX-13 is a first-in-class, orally active and gut-restricted agent that selectively targets and activates the NLRX1 pathway to induce immunometabolic changes. NX-13 results in lower inflammation and responses in inflammatory bowel disease. NX-13 can be used for the research of crohn's disease and ulcerative colitis[1][2].
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Amelenodor | NX-13 is a first-in-class, orally active and gut-restricted agent that selectively targets and activates the NLRX1 pathway to induce immunometabolic changes. NX-13 results in lower inflammation and responses in inflammatory bowel disease. NX-13 can be used for the research of crohn's disease and ulcerative colitis. | |||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.55
HY-W4566004,4'-(Pyridine-2,6-diylbis(oxy))dibenzoic acid -
Similarity Score 0.53
HY-W0753404,4',4''-(Benzene-1,3,5-triyltris(oxy))tribenzoic acid -
Similarity Score 0.52
![2,4,6-Tris-(pyridin-4-yloxy)-[1,3,5]triazine Chemical Structure](//file.medchemexpress.com/product_pic/hy-w112643.gif)
HY-W1126432,4,6-Tris-(pyridin-4-yloxy)-[1,3,5]triazine -
Similarity Score 0.51
HY-W1127901,3,5-Tris(pyridin-4-ylmethoxy)benzene -
Similarity Score 0.50
HY-W4563684,4'-(1,3-Phenylenebis(oxy))dibenzoic acid -
Similarity Score 0.49
HY-W1124584,4'-((5-Carboxy-1,3-phenylene)bis(oxy))dibenzoic acid -
Similarity Score 0.49
HY-B2031Pyriproxyfen -
Similarity Score 0.49
HY-W0086804,4'-Bis(4-aminophenoxy)biphenyl -
Similarity Score 0.48
HY-W5870191,3,5-Tris(2,6-dimethylpyridin-4-yl)benzene -
Explore the MedChemAI to find more analogs
![2,4,6-Tris-(pyridin-4-yloxy)-[1,3,5]triazine Chemical Structure](http://file.medchemexpress.com/product_pic/hy-w112643.gif)
References
- [1]. Leber A, et al. Activation of NLRX1 by NX-13 Alleviates Inflammatory Bowel Disease through Immunometabolic Mechanisms in CD4+ T Cells. J Immunol. 2019;203(12):3407-3415. [Content Brief]
- [2]. Leber A, et.al. Exploratory studies with NX-13: oral toxicity and pharmacokinetics in rodents of an orally active, gut-restricted first-in-class therapeutic for IBD that targets NLRX1 [published online ahead of print, 2019 Oct 25]. Drug Chem Toxicol. 2019;1-6. [Content Brief]
