2389235-01-0
2389235-01-0
Chemical Structure
Amelenodor
Synonym(s): NX-13
- CAS No.: 2389235-01-0
- Formula:C24H21N3O3
- Molecular Weight:399.44
IUPAC Name: 1,3,5-tris((6-methylpyridin-2-yl)oxy)benzene
InChIKey: OPUQKVNCXCWRLR-UHFFFAOYSA-N
SMILES: CC1=NC(OC2=CC(OC3=CC=CC(C)=N3)=CC(OC4=CC=CC(C)=N4)=C2)=CC=C1
Biological Activity: NX-13 is a first-in-class, orally active and gut-restricted agent that selectively targets and activates the NLRX1 pathway to induce immunometabolic changes. NX-13 results in lower inflammation and responses in inflammatory bowel disease. NX-13 can be used for the research of crohn's disease and ulcerative colitis[1][2].
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Amelenodor | NX-13 is a first-in-class, orally active and gut-restricted agent that selectively targets and activates the NLRX1 pathway to induce immunometabolic changes. NX-13 results in lower inflammation and responses in inflammatory bowel disease. NX-13 can be used for the research of crohn's disease and ulcerative colitis. | |||||||||||||||||||||
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References
- [1]. Leber A, et al. Activation of NLRX1 by NX-13 Alleviates Inflammatory Bowel Disease through Immunometabolic Mechanisms in CD4+ T Cells. J Immunol. 2019;203(12):3407-3415. [Content Brief]
- [2]. Leber A, et.al. Exploratory studies with NX-13: oral toxicity and pharmacokinetics in rodents of an orally active, gut-restricted first-in-class therapeutic for IBD that targets NLRX1 [published online ahead of print, 2019 Oct 25]. Drug Chem Toxicol. 2019;1-6. [Content Brief]
