2412008-91-2
Chemical Structure
TRK-IN-18
- CAS No.: 2412008-91-2
- Formula:C25H23F2N5O2S
- Molecular Weight:495.54
IUPAC Name: 6-((2R,4S)-4-fluoro-2-(5-fluoro-2-(methylthio)phenyl)pyrrolidin-1-yl)-N-(3-hydroxybenzyl)imidazo[1,2-b]pyridazine-3-carboxamide
InChIKey: ZEBCRZRAVKXXBI-FXAWDEMLSA-N
SMILES: CSC1=C(C=C(C=C1)F)[C@H]2C[C@@H](CN2C3=NN4C(C(NCC5=CC(O)=CC=C5)=O)=CN=C4C=C3)F
Biological Activity: TRK-IN-18 is a potent inhibitor of TRK. Tropomyosin-related kinases (Trks) are a family of receptor tyrosine kinases activated by neurotrophins, a group of soluble growth factors including Nerve Growth Factor (NGF), Brain-Derived Neurotrophic Factor (BDNF) and Neurotrophin-3 (NT-3) and Neurotrophin-4/5 (NT-4/5). TRK-IN-18 has the potential for the research of cancer diseases (extracted from patent WO2021148805A1, compound 7)[1].
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TRK-IN-18 | TRK-IN-18 is a potent inhibitor of TRK. Tropomyosin-related kinases (Trks) are a family of receptor tyrosine kinases activated by neurotrophins, a group of soluble growth factors including Nerve Growth Factor (NGF), Brain-Derived Neurotrophic Factor (BDNF) and Neurotrophin-3 (NT-3) and Neurotrophin-4/5 (NT-4/5). TRK-IN-18 has the potential for the research of cancer diseases (extracted from patent WO2021148805A1, compound 7). | |||||||||||||||||||||
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