2413816-64-3
Chemical Structure
CEMT
- CAS No.: 2413816-64-3
- Formula:C26H21Cl2NO4
- Molecular Weight:482.36
InChIKey: GHJKAQMHBIBNMR-UHDJGPCESA-M
SMILES: CC(OC1=CC=C2C=C(C(OC2=C1)=O)/C=C/C3=CC=[N+](C=C3)CC4=CC=C(C=C4)CCl)=O.[Cl-]
Biological Activity: CEMT is a carboxylesterase (CES) substrate and a ratiometric two-photon fluorescent reporter probe. CEMT can be hydrolyzed by CES to generate HMT, which is used for mitochondrial pH sensing. After activation by CES, CEMT exhibits ratiometric fluorescence changes in response to pH variations. CEMT targets and covalently binds to mitochondria, and can avoid leakage during acidification, thus enabling in situ imaging (Ex/Em = 410 nm/550 nm)[1].
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CEMT | CEMT is a carboxylesterase (CES) substrate and a ratiometric two-photon fluorescent reporter probe. CEMT can be hydrolyzed by CES to generate HMT, which is used for mitochondrial pH sensing. After activation by CES, CEMT exhibits ratiometric fluorescence changes in response to pH variations. CEMT targets and covalently binds to mitochondria, and can avoid leakage during acidification, thus enabling in situ imaging (Ex/Em = 410 nm/550 nm). | |||||||||||||||||||||
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Keywords
