Ratiometric two-photon fluorescent probe for in situ imaging of carboxylesterase (CE)-mediated mitochondrial acidification during medication

  • Chem Commun (Camb). 2019 Sep 19;55(76):11358-11361. doi: 10.1039/c9cc05759e.
Ao Jiang  1 ,  Guang Chen ,  Jie Xu ,  Yuxia Liu ,  Guanghui Zhao ,  Zhenjun Liu ,  Tao Chen ,  Yulin Li ,  Tony D James
Affiliations
  • 1. The Key Laboratory of Life-Organic Analysis, Key Laboratory of Pharmaceutical Intermediates and Analysis of Natural Medicine, College of Chemistry and Chemical Engineering, Qufu Normal University, The school attached to Qufu Normal University, Qufu 273165, China. [email protected].
PMID: 31482158 DOI: 10.1039/c9cc05759e
Abstract

We report on a dual ratiometric two-photon fluorescent probe for in situ sensing of mitochondrial CE activity and pH. Using the probe it is possible to visualize the CE-mediated acidification of hepatoma cells and hepatic tissues during medication with antipyretic anti-inflammatory drugs.

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