2415076-25-2
Chemical Structure
Tyk2-IN-29
- CAS No.: 2415076-25-2
- Formula:C21H18Cl2N4O5S
- Molecular Weight:509.36
IUPAC Name: 2-(2,6-dichlorophenyl)-5-((4-(1,1-dioxidothiomorpholine-4-carbonyl)phenyl)amino)oxazole-4-carboxamide
InChIKey: DVDLLEFLTHKNDQ-UHFFFAOYSA-N
SMILES: O=C(N)C=1N=C(OC1NC2=CC=C(C=C2)C(=O)N3CCS(=O)(=O)CC3)C=4C(Cl)=CC=CC4Cl
Biological Activity: Tyk2-IN-29 is a potent and selective TYK2 kinase inhibitor with an IC50 of 1.9 nM. Tyk2-IN-29 blocks the downstream JAK-STAT signaling pathway mediated by IL-23/IL-12 through potent inhibition of the target TYK2 kinase (inhibiting STAT3 phosphorylation and IL-17F production). Tyk2-IN-29 can be used for research on autoimmune diseases[1][2].
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Tyk2-IN-29 | Tyk2-IN-29 is a potent and selective TYK2 kinase inhibitor with an IC50 of 1.9 nM. Tyk2-IN-29 blocks the downstream JAK-STAT signaling pathway mediated by IL-23/IL-12 through potent inhibition of the target TYK2 kinase (inhibiting STAT3 phosphorylation and IL-17F production). Tyk2-IN-29 can be used for research on autoimmune diseases. | |||||||||||||||||||||
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