244072-26-2
Chemical Structure
CAA-0225
- CAS No.: 244072-26-2
- Formula:C28H29N3O5
- Molecular Weight:487.55
IUPAC Name: (2S,3S)-N2-((S)-1-(benzylamino)-1-oxo-3-phenylpropan-2-yl)-N3-(4-hydroxyphenethyl)oxirane-2,3-dicarboxamide
InChIKey: ZMZQYVMNDRBKLO-SDHOMARFSA-N
SMILES: O=C([C@H]1O[C@@H]1C(N[C@@H](CC2=CC=CC=C2)C(NCC3=CC=CC=C3)=O)=O)NCCC4=CC=C(O)C=C4
Biological Activity: CAA-0225 is a tissue protease L inhibitor that inhibits rat liver tissue protease L with a IC50 value of 1.9 nM. CAA-0225 can participate in the degradation of autophagosome membrane markers LC3-II and GABARAP (HY-P72639), improve cardiac function in mice with reperfusion injury, and kill and eliminate Trypanosoma brucei parasites[1][2][3].
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CAA-0225 | CAA-0225 is a tissue protease L inhibitor that inhibits rat liver tissue protease L with a IC50 value of 1.9 nM. CAA-0225 can participate in the degradation of autophagosome membrane markers LC3-II and GABARAP (HY-P72639), improve cardiac function in mice with reperfusion injury, and kill and eliminate Trypanosoma brucei parasites. | |||||||||||||||||||||
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