2446817-72-5
Chemical Structure
APOL1-IN-1
- CAS No.: 2446817-72-5
- Formula:C21H20FN3O3
- Molecular Weight:381.40
IUPAC Name: 3-(2-(4-fluorophenyl)-1H-indol-3-yl)-N-((3S,4R)-4-hydroxy-2-oxopyrrolidin-3-yl)propanamide
InChIKey: CNYZYDUBGMRAFP-XLIONFOSSA-N
SMILES: O=C(N[C@@H]1C(NC[C@H]1O)=O)CCC2=C(C3=CC=C(F)C=C3)NC4=C2C=CC=C4
Biological Activity: APOL1-IN-1 is an apolipoprotein L1 (APOL1) inhibitor that suppresses the functional activity of the APOL1 G1 risk variant. APOL1-IN-1 inhibits the pore function of APOL1, thereby reducing APOL1-mediated membrane permeability and abnormal ion flux, and thus intervenes in APOL1-related cellular injury processes. APOL1-IN-1 is used in research related to focal segmental glomerulosclerosis and non-diabetic kidney disease[1].
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APOL1-IN-1 | 99.85% | APOL1-IN-1 is an apolipoprotein L1 (APOL1) inhibitor that suppresses the functional activity of the APOL1 G1 risk variant. APOL1-IN-1 inhibits the pore function of APOL1, thereby reducing APOL1-mediated membrane permeability and abnormal ion flux, and thus intervenes in APOL1-related cellular injury processes. APOL1-IN-1 is used in research related to focal segmental glomerulosclerosis and non-diabetic kidney disease. | ||||||||||||||||||||
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