2452019-67-7
2452019-67-7
Chemical Structure
FLT3/CDKs ligand-1
- CAS No.: 2452019-67-7
- Formula:C26H31N9O3
- Molecular Weight:517.58
InChIKey: NTWVVDYWEBCPNA-UHFFFAOYSA-N
SMILES: O=C(C1=NNC=C1NC2=C3C(NC=C3)=NC=N2)NC4=CC=C(CN5CCN(C(OC(C)(C)C)=O)CC5)C=C4
Biological Activity: FLT3/CDKs ligand-1 (Compound 14) is a ligand for target protein, which promotes the degradation of cyclin-dependent kinase (CDK) and the FMS-like tyrosine kinase 3 (FLT3), inhibits FLT3/CDK related proliferations and survivals of leukemia cells. LT3/CDKs ligand-1 can be used for synthesis of PROTAC FLT3/CDKs degrader-1 (HY-161708)[1].
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FLT3/CDKs ligand-1 | FLT3/CDKs ligand-1 (Compound 14) is a ligand for target protein, which promotes the degradation of cyclin-dependent kinase (CDK) and the FMS-like tyrosine kinase 3 (FLT3), inhibits FLT3/CDK related proliferations and survivals of leukemia cells. LT3/CDKs ligand-1 can be used for synthesis of PROTAC FLT3/CDKs degrader-1 (HY-161708). | |||||||||||||||||||||
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References
Keywords
