24527-27-3
Chemical Structure
Spiclomazine
Synonym(s): Clospirazine
- CAS. Nr.: 24527-27-3
- Formula:C22H24ClN3OS2
- Molecular Weight:446.03
IUPAC Name: 8-(3-(2-chloro-10H-phenothiazin-10-yl)propyl)-1-thia-4,8-diazaspiro[4.5]decan-3-one
InChIKey: CFOYBMUYCBSDAL-UHFFFAOYSA-N
SMILES: O=C1CSC2(CCN(CCCN3C4=C(C=CC=C4)SC5=CC=C(Cl)C=C35)CC2)N1
Biological Activity: Spiclomazine (Clospirazine) is a potent mutant KRAS(G12C) inhibitor that selectively inhibits mutant KRAS-driven pancreatic cancer. Spiclomazine can eliminate KRas-GTP levels in KRAS-driven pancreatic cancer and effectively inhibit RAS-mediated signaling. Spiclomazine significantly inhibits tumor progression in mouse renal capsule xenotransplantation models[1].
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Spiclomazine | 99.56% | Spiclomazine (Clospirazine) is a potent mutant KRAS(G12C) inhibitor that selectively inhibits mutant KRAS-driven pancreatic cancer. Spiclomazine can eliminate KRas-GTP levels in KRAS-driven pancreatic cancer and effectively inhibit RAS-mediated signaling. Spiclomazine significantly inhibits tumor progression in mouse renal capsule xenotransplantation models. | ||||||||||||||||||||
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