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Cat. No.: HY-137088

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Imiclopazine

Imiclopazine is a phenothiazine derivative with with psychomotor stabilizing properties, antiaggressive and antiemetic effects.

For research use only. We do not sell to patients.

CAS No.: 7414-95-1
Formula: C₂₅H₃₄Cl₃N₅OS
Molecular Weight:558.99

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

Imiclopazine Chemical Structure

CAS No.: 7414-95-1

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Imiclopazine is a phenothiazine derivative with with psychomotor stabilizing properties, antiaggressive and antiemetic effects^[1].

In Vitro

Imiclopazine shows multidrug-resistance (MDR)-reversal activity in P388 and P388/ADR cells, with EC₅₀ values of both 200 μM^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 7414-95-1
Molecular Weight 558.99
Formula C₂₅H₃₄Cl₃N₅OS
SMILES

O=C1N(C)CCN1CCN2CCN(CCCN3C4=C(C=CC=C4)SC5=CC=C(Cl)C=C35)CC2.[H]Cl.[H]Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. A Ramu, et al. Reversal of multidrug resistance by phenothiazines and structurally related compounds. Cancer Chemother Pharmacol. 1992;30(3):165-73. [Content Brief]

[2]. D. Lenke, et al. Pharmacological activity of new phenothiazine and azaphenothiazine derivatives. January 1971, Arzneimittel-Forschung. 21:288-293.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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