2475658-75-2
Chemical Structure
HIV-1 inhibitor-24
- CAS No.: 2475658-75-2
- Formula:C26H19N5O2
- Molecular Weight:433.46
IUPAC Name: (S)-4'-((2-((4-cyanophenyl)amino)pyrimidin-4-yl)(hydroxy)methyl)-3'-methoxy-[1,1'-biphenyl]-4-carbonitrile
InChIKey: UHMLHIRSNCDVOO-VWLOTQADSA-N
SMILES: N#CC1=CC=C(C2=CC=C([C@@H](C3=NC(NC4=CC=C(C#N)C=C4)=NC=C3)O)C(OC)=C2)C=C1
Biological Activity: HIV-1 inhibitor-24 (compound S-12a) is a highly potent HIV-1 reverse transcriptase, with an IC50 value of 9.5 nM. HIV-1 inhibitor-24 has high antiretroviral activity against WT HIV-1 with an EC50 of 1.6 nM, and exhibits relatively low cytotoxicity with a CC50 of 9.07 μM in MT-4 cells. HIV-1 inhibitor-24 is well tolerated at a dose of 2 g/kg in mice and has a significant cardiovascular safety[1].
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HIV-1 inhibitor-24 | HIV-1 inhibitor-24 (compound S-12a) is a highly potent HIV-1 reverse transcriptase, with an IC50 value of 9.5 nM. HIV-1 inhibitor-24 has high antiretroviral activity against WT HIV-1 with an EC50 of 1.6 nM, and exhibits relatively low cytotoxicity with a CC50 of 9.07 μM in MT-4 cells. HIV-1 inhibitor-24 is well tolerated at a dose of 2 g/kg in mice and has a significant cardiovascular safety. | |||||||||||||||||||||
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