2489231-47-0
Chemical Structure
CHET3
- CAS No.: 2489231-47-0
- Formula:C21H21N5O3S
- Molecular Weight:423.49
InChIKey: TWOGFEZVVKEUDZ-UHFFFAOYSA-N
SMILES: CC(C=C1)=CC=C1SCC(NC(NC(NC2=CC=C(OCCO3)C3=C2)=N)=N4)=CC4=O
Biological Activity: CHET3 is a sex-selective activator with potent analgesic activity. CHET3 was discovered to be a highly selective omnidirectional modulator of TASK-3-containing K2P channels, including TASK-3 homologues and TASK-3/TASK-1 heterologues. CHET3 exhibited significant analgesic effects in multiple acute and chronic pain models in mice, which could be abolished by pharmacological means or genetic knockout of TASK-3. CHET3 is able to functionally modulate the membrane excitability of specific small sensory neurons, which supports its analgesic effects on thermal hypersensitivity and mechanical hyperalgesia in chronic pain[1].
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CHET3 | 99.75% | CHET3 is a sex-selective activator with potent analgesic activity. CHET3 was discovered to be a highly selective omnidirectional modulator of TASK-3-containing K2P channels, including TASK-3 homologues and TASK-3/TASK-1 heterologues. CHET3 exhibited significant analgesic effects in multiple acute and chronic pain models in mice, which could be abolished by pharmacological means or genetic knockout of TASK-3. CHET3 is able to functionally modulate the membrane excitability of specific small sensory neurons, which supports its analgesic effects on thermal hypersensitivity and mechanical hyperalgesia in chronic pain. | ||||||||||||||||||||
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Keywords
