2548725-57-9
2548725-57-9
Chemical Structure
DNMT/HDAC-IN-2
- CAS No.: 2548725-57-9
- Formula:C28H38N4O5
- Molecular Weight:510.63
InChIKey: MVOUQHUJONCQCX-UHFFFAOYSA-N
SMILES: COC1=C(C=C(C2=C1)N=C(C=C2NC3CCN(CC3)C)C4=CC=C(O4)C)OCCCCCCC(NO)=O
Biological Activity: DNMT/HDAC-IN-2 (Compound Y7) is a DNMT and HDAC inhibitor with IC50 values for DNMT1, HDAC1, and HDAC6 of 365, 0.2, and 8.91 nM respectively. DNMT/HDAC-IN-2 inhibits the proliferation of breast cancer cells. DNMT/HDAC-IN-2 significantly reduces tumor growth in xenografts and transgenic breast cancer mouse models. DNMT/HDAC-IN-2 can be used for the study of breast cancer[1].
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DNMT/HDAC-IN-2 | DNMT/HDAC-IN-2 (Compound Y7) is a DNMT and HDAC inhibitor with IC50 values for DNMT1, HDAC1, and HDAC6 of 365, 0.2, and 8.91 nM respectively. DNMT/HDAC-IN-2 inhibits the proliferation of breast cancer cells. DNMT/HDAC-IN-2 significantly reduces tumor growth in xenografts and transgenic breast cancer mouse models. DNMT/HDAC-IN-2 can be used for the study of breast cancer. | |||||||||||||||||||||
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References
Keywords
