25627-36-5
Chemical Structure
(E)-Dothiepin hydrochloride
Synonym(s): (E)-Dosulepin hydrochloride; (E)-Dothep hydrochloride
- CAS No.: 25627-36-5
- Formula:C19H22ClNS
- Molecular Weight:331.90
InChIKey: XUPZAARQDNSRJB-SJDTYFKWSA-N
SMILES: CN(C)CC/C=C1C2=CC=CC=C2CSC3=CC=CC=C3\1.Cl
Biological Activity: (E)-Dothiepin ((E)-Dosulepin;(E)-Dothep) hydrochloride is an antidepressant agent with sedative/anxiolytic activity. (E)-Dothiepin hydrochloride is an inhibitor preferring of noradrenaline uptake than serotonin uptake. (E)-Dothiepin hydrochloride facilitates noradrenergic neurotransmission via inhibiting the neuronal uptake. (E)-Dothiepin hydrochloride is also an antagonist of histamine H1-receptor without cardiotoxicity. (E)-Dothiepin hydrochloride exhibits significant analgesic activity in psychogenic facial pain，idiopathic fibromyalgia syndrome or rheumatoid arthritis[1].
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(E)-Dothiepin hydrochloride | (E)-Dothiepin ((E)-Dosulepin;(E)-Dothep) hydrochloride is an antidepressant agent with sedative/anxiolytic activity. (E)-Dothiepin hydrochloride is an inhibitor preferring of noradrenaline uptake than serotonin uptake. (E)-Dothiepin hydrochloride facilitates noradrenergic neurotransmission via inhibiting the neuronal uptake. (E)-Dothiepin hydrochloride is also an antagonist of histamine H1-receptor without cardiotoxicity. (E)-Dothiepin hydrochloride exhibits significant analgesic activity in psychogenic facial pain，idiopathic fibromyalgia syndrome or rheumatoid arthritis. | |||||||||||||||||||||
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