257612-36-5
257612-36-5
Chemical Structure
Synstab A
- CAS. Nr.: 257612-36-5
- Formula:C15H13BrCl3N3O3S
- Molecular Weight:501.61
IUPAC Name: 4-bromo-N-(2,2,2-trichloro-1-((4-sulfamoylphenyl)amino)ethyl)benzamide
InChIKey: FMFJXSOLIQFTSJ-UHFFFAOYSA-N
SMILES: O=C(C1=CC=C(C=C1)Br)NC(C(Cl)(Cl)Cl)NC2=CC=C(C=C2)S(=O)(N)=O
Biological Activity: Synstab A is a mitosis modulator to promote interactions between α- and β-tubulin. Synstab A can polymerizes microtubules from purified tubulin, and produces microtubule bundles in interphase cells[1][2].
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Synstab A | Synstab A is a mitosis modulator to promote interactions between α- and β-tubulin. Synstab A can polymerizes microtubules from purified tubulin, and produces microtubule bundles in interphase cells. | |||||||||||||||||||||
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References
- [1]. Gerry CJ, et al. Unifying principles of bifunctional, proximity-inducing small molecules. Nat Chem Biol. 2020 Apr;16(4):369-378. [Content Brief]
- [2]. Beyer CF, et al. TTI-237: a novel microtubule-active compound with in vivo antitumor activity. Cancer Res. 2008 Apr 1;68(7):2292-300. [Content Brief]
Keywords
