Mitosis Modulator
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MELK-8a hydrochloride
0 ImagesSynonyms: NVS-MELK8a hydrochlorideMELK-8a hydrochloride (NVS-MELK8a hydrochloride) is an ATP-competitive, selective MELK inhibitor with an IC50 value of 0.002 μM. MELK-8a hydrochloride inhibits NF-κB signaling. MELK-8a hydrochloride induces G2/M checkpoint activation, delayed mitotic entry, G2 phase prolongation, and delayed activation of Aurora A/B and CDK1. MELK-8a hydrochloride inhibits melanoma. MELK-8a hydrochloride can be used for research on triple-negative breast cancer.
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SIC5-6
0 ImagesSIC5-6 is a potent Separase inhibitor. Separase, a large cysteine protease, involves in chromosome segregation during mitosis and meiosis, DNA damage repair, centrosome disengagement and duplication, spindle stabilization and elongation. Separase is highly overexpressed in many solid cancers, serves as an attractive chemotherapeutic target.
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MELK-8a
0 ImagesSynonyms: NVS-MELK8aMELK-8a (NVS-MELK8a) is an ATP-competitive, selective MELK inhibitor with an IC50 value of 0.002 μM. MELK-8a inhibits NF-κB signaling. MELK-8a induces G2/M checkpoint activation, delayed mitotic entry, G2 phase prolongation, and delayed activation of Aurora A/B and CDK1. MELK-8a inhibits melanoma. MELK-8a can be used for research on triple-negative breast cancer.
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P34cdc2 Kinase Fragment
0 ImagesCat. No.: HY-P3894CAS No.: 309247-52-7P34cdc2 Kinase Fragment is associated with the completion of DNA replication in yeast mitosis. P34cdc2 Kinase can phosphorylate mitogen-activated protein 2 (MAP2) to regulate microtubules polymerization in Xenopus oocytes meiosis.
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Synstab A
0 ImagesCat. No.: HY-116915CAS No.: 257612-36-5Synstab A is a mitosis modulator to promote interactions between α- and β-tubulin. Synstab A can polymerizes microtubules from purified tubulin, and produces microtubule bundles in interphase cells.
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AurkA allosteric-IN-1
0 ImagesCat. No.: HY-158038CAS No.: 3035323-39-5AurkA allosteric-IN-1 (compound 6h) is an Aurora A (AurkA) inhibitor (IC50: 6.50 μM) that inhibits the catalytic activity and non-catalytic functions of Aurora A. Aurora A regulates the assembly of the bipolar mitotic spindle and the fidelity of chromosome segregation during mitosis and has non-catalytic functions. AurkA allosteric-IN-1 blocks the interaction of AurkA with the activator TPX2 by binding to the Y pocket of AurkA.
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MELK-8a hydrochloride (Standard)
0 ImagesCat. No.: HY-100368ARCAS No.: 2096992-20-8Synonyms: NVS-MELK8a hydrochloride (Standard)MELK-8a hydrochloride (Standard) (NVS-MELK8a hydrochloride (Standard)) is the analytical standard of MELK-8a hydrochloride (HY-100368A). This product is intended for research and analytical applications. MELK-8a hydrochloride (NVS-MELK8a hydrochloride) is an ATP-competitive, selective MELK inhibitor with an IC50 value of 0.002 μM. MELK-8a hydrochloride inhibits NF-κB signaling. MELK-8a hydrochloride induces G2/M checkpoint activation, delayed mitotic entry, G2 phase prolongation, and delayed activation of Aurora A/B and CDK1. MELK-8a hydrochloride inhibits melanoma. MELK-8a hydrochloride can be used for research on triple-negative breast cancer.
