P34cdc2 Kinase Fragment
P34cdc2 Kinase Fragment is associated with the completion of DNA replication in yeast mitosis. P34cdc2 Kinase can phosphorylate mitogen-activated protein 2 (MAP2) to regulate microtubules polymerization in Xenopus oocytes meiosis.
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- CAS No.: 309247-52-7
- Formula: C39H70N12O13S2
- Molecular Weight:979.18
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
Mitogen-activated protein 2[2]
Chemical Information
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CAS No. 309247-52-7
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Molecular Weight 979.18
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Formula C39H70N12O13S2
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Sequence Shortening
CDNQIKKM
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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PCNA Immunodetection Proliferation Assay
PCNA immunodetection measures proliferative activity by detecting proliferating cell nuclear antigen, a nuclear protein associated with DNA polymerase δ function and DNA replication. The assay readout is the proportion of PCNA-positive nuclei among total counted cells, but PCNA labeling is not identical to BrdU labeling because PCNA can mark late G1/early S-associated replication competence and may persist beyond active DNA synthesis depending on fixation and extraction conditions.
Purity & Documentation
References
[1]. Knudsen KE, et al. p34cdc2 kinase activity is maintained upon activation of the replication checkpoint in Schizosaccharomyces pombe. Proc Natl Acad Sci U S A. 1996 Aug 6;93(16):8278-83. [Content Brief]
[2]. Fellous A, et al. Association of p34cdc2 kinase and MAP kinase with microtubules during the meiotic maturation of Xenopus oocytes. Int J Dev Biol. 1994 Dec;38(4):651-9. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
P34cdc2 Kinase Fragment Related Classifications
HY-P3894 Related Classifications
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