257892-33-4
257892-33-4
Chemical Structure
AWD 12-281
Synonym(s): GW 842470
- CAS No.: 257892-33-4
- Formula:C22H14Cl2FN3O3
- Molecular Weight:458.27
IUPAC Name: N-(3,5-dichloropyridin-4-yl)-2-(1-(4-fluorobenzyl)-5-hydroxy-1H-indol-3-yl)-2-oxoacetamide
InChIKey: DPHDSIQHVGSITN-UHFFFAOYSA-N
SMILES: O=C(C(C1=CN(CC2=CC=C(C=C2)F)C3=C1C=C(O)C=C3)=O)NC4=C(Cl)C=NC=C4Cl
Biological Activity: AWD 12-281 is an orally active and highly selective phosphodiesterase 4 (PDE4) inhibitor (IC50 = 9.7 nM). AWD 12-281 is used in the study of allergic dermatitis, asthma, chronic obstructive pulmonary disease (COPD), and allergic rhinitis[1][2].
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AWD 12-281 | 98.07% | AWD 12-281 is an orally active and highly selective phosphodiesterase 4 (PDE4) inhibitor (IC50 = 9.7 nM). AWD 12-281 is used in the study of allergic dermatitis, asthma, chronic obstructive pulmonary disease (COPD), and allergic rhinitis. | ||||||||||||||||||||
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References
- [1]. Wolfgang Bäumer, et al. AWD 12-281, a highly selective phosphodiesterase 4 inhibitor, is effective in the prevention and treatment of inflammatory reactions in a model of allergic dermatitis. J Pharm Pharmacol. 2003 Aug;55(8):1107-14. [Content Brief]
- [2]. Regina Draheim, et al. Anti-inflammatory potential of the selective phosphodiesterase 4 inhibitor N-(3,5-dichloro-pyrid-4-yl)-[1-(4-fluorobenzyl)-5-hydroxy-indole-3-yl]-glyoxylic acid amide (AWD 12-281), in human cell preparations. J Pharmacol Exp Ther. 2004 Feb;308(2):555-63. [Content Brief]
