2579689-85-1
Chemical Structure
CXCR6 antagonist 1
- CAS No.: 2579689-85-1
- Formula:C27H30F3N3O4S
- Molecular Weight:549.61
IUPAC Name: 3,4,5-trimethoxy-N-((1R,3s,5S)-9-((4-(trifluoromethyl)benzo[d]thiazol-2-yl)methyl)-9-azabicyclo[3.3.1]nonan-3-yl)benzamide
InChIKey: OZAGNFAFPKLYFB-NNZMDNLPSA-N
SMILES: C(N1[C@@]2(C[C@H](NC(=O)C3=CC(OC)=C(OC)C(OC)=C3)C[C@]1(CCC2)[H])[H])C4=NC=5C(S4)=CC=CC5C(F)(F)F
Biological Activity: CXCR6 antagonist 1 (Compound 81) is an orally active CXCR6 antagonist. CXCR6 antagonist 1 inhibits the CXCR6 receptor signaling pathway, including β-arrestin recruitment and Forskolin (HY-15371)-induced cAMP production. CXCR6 antagonist 1 reduces tumor growth in a mouse xenograft model of hepatocellular carcinoma. CXCR6 antagonist 1 can be used in research related to hepatocellular carcinoma[1].
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CXCR6 antagonist 1 | CXCR6 antagonist 1 (Compound 81) is an orally active CXCR6 antagonist. CXCR6 antagonist 1 inhibits the CXCR6 receptor signaling pathway, including β-arrestin recruitment and Forskolin (HY-15371)-induced cAMP production. CXCR6 antagonist 1 reduces tumor growth in a mouse xenograft model of hepatocellular carcinoma. CXCR6 antagonist 1 can be used in research related to hepatocellular carcinoma. | |||||||||||||||||||||
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