2581114-83-0
Chemical Structure
BACE1-IN-5
- CAS No.: 2581114-83-0
- Formula:C18H16F5N5O2S
- Molecular Weight:461.41
IUPAC Name: N-(3-((4S,6S)-2-amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-thiazin-4-yl)-4-fluorophenyl)-5-(fluoromethoxy)pyrazine-2-carboxamide
InChIKey: JRPAQOLQALFUAQ-GUYCJALGSA-N
SMILES: O=C(C1=NC=C(OCF)N=C1)NC2=CC=C(F)C([C@@]3(C)N=C(N)S[C@H](C(F)(F)F)C3)=C2
Biological Activity: BACE1-IN-5 (Compound 15) is a β-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitor with an IC50 of 9.1 nM, and also inhibits cellular amyloid-β (Aβ) with an IC50 of 0.82 nM. BACE1-IN-5 has a medicinal chemistry that improves hERG inhibition and P-gp efflux[1].
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BACE1-IN-5 | BACE1-IN-5 (Compound 15) is a β-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitor with an IC50 of 9.1 nM, and also inhibits cellular amyloid-β (Aβ) with an IC50 of 0.82 nM. BACE1-IN-5 has a medicinal chemistry that improves hERG inhibition and P-gp efflux. | |||||||||||||||||||||
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Keywords
