25905-77-5
Chemical Structure
Minaprine
- CAS No.: 25905-77-5
- Formula:C17H22N4O
- Molecular Weight:298.38
IUPAC Name: 4-methyl-N-(2-morpholinoethyl)-6-phenylpyridazin-3-amine
InChIKey: LDMWSLGGVTVJPG-UHFFFAOYSA-N
SMILES: CC1=CC(C2=CC=CC=C2)=NN=C1NCCN3CCOCC3
Biological Activity: Minaprine is a brain-penetrant monoamine oxidase inhibitor. Minaprine also weakly inhibits acetylcholinesterase (AChE) activity. Minaprine reduces intraneuronal dopamine metabolism, lowers striatal homovanillic acid and dihydroxyphenylacetic acid levels, and raises striatal 3-methoxytyramine and 5-hydroxytryptamine levels. Minaprine exhibits convulsant, antidepressant properties[1][2].
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Minaprine | Minaprine is a brain-penetrant monoamine oxidase inhibitor. Minaprine also weakly inhibits acetylcholinesterase (AChE) activity. Minaprine reduces intraneuronal dopamine metabolism, lowers striatal homovanillic acid and dihydroxyphenylacetic acid levels, and raises striatal 3-methoxytyramine and 5-hydroxytryptamine levels. Minaprine exhibits convulsant, antidepressant properties. | |||||||||||||||||||||
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- [1]. Ferretti P, et al. Biochemical effects of minaprine on striatal dopaminergic neurons in rats. J Pharm Pharmacol. 1984;36(1):48-50. [Content Brief]
- [2]. Garattini S, et al. Neurochemical effects of minaprine, a novel psychotropic drug, on the central cholinergic system of the rat. Psychopharmacology (Berl). 1984;82(3):210-214. [Content Brief]
Keywords
