2593402-36-7
Chemical Structure
JAK2-IN-7
- CAS. Nr.: 2593402-36-7
- Formula:C26H33N7O
- Molecular Weight:459.59
IUPAC Name: (E)-4-(dimethylamino)-1-(6-((4-(1-isopropyl-1H-pyrazol-4-yl)-5-methylpyrimidin-2-yl)amino)-3,4-dihydroisoquinolin-2(1H)-yl)but-2-en-1-one
InChIKey: SURRDPSGERGIIM-VOTSOKGWSA-N
SMILES: CC1=C(N=C(N=C1)NC2=CC=C3CN(CCC3=C2)C(/C=C/CN(C)C)=O)C4=CN(N=C4)C(C)C
Biological Activity: JAK2-IN-7 is a selective JAK2 inhibitor with IC50s of 3, 11.7, and 41 nM for JAK2, SET-2, and Ba/F3V617F cells, respectively. JAK2-IN-7 possesses >14-fold selectivity over JAK1, JAK3, FLT3. JAK2-IN-7 stimulates cell cycle arrest in the G0/G1 phase and induces tumor cellapoptosis. Antitumor activities[1].
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JAK2-IN-7 | 98.31% | JAK2-IN-7 is a selective JAK2 inhibitor with IC50s of 3, 11.7, and 41 nM for JAK2, SET-2, and Ba/F3V617F cells, respectively. JAK2-IN-7 possesses >14-fold selectivity over JAK1, JAK3, FLT3. JAK2-IN-7 stimulates cell cycle arrest in the G0/G1 phase and induces tumor cellapoptosis. Antitumor activities. | ||||||||||||||||||||
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